Caspase Cascades in Human Immunodeficiency Virus-Associated Neurodegeneration

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Caspase cascades in human immunodeficiency virus-associated neurodegeneration.

Many patients infected with human immunodeficiency virus-1 (HIV-1) develop a syndrome of neurologic deterioration known as HIV-associated dementia (HAD). Neurons are not productively infected by HIV-1; thus, the mechanism of HIV-induced neuronal injury remains incompletely understood. Several investigators have observed evidence of neuronal injury, including dendritic degeneration, and apoptosi...

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ژورنال

عنوان ژورنال: The Journal of Neuroscience

سال: 2002

ISSN: 0270-6474,1529-2401

DOI: 10.1523/jneurosci.22-10-04015.2002